| 1800 |
Pierre Samuel du Pont de Nemours, sons Victor Marie and Eleuthère Irénée, and their families arrive in America. |
| 1802 |
The du Pont family settles in the Brandywine Valley. E. I. du Pont establishes gunpowder manufactory, E. I. du Pont de Nemours & Co. |
| 1810-18 |
E. I. du Pont purchases four tracts of land forming the nucleus of what later becomes Winterthur. |
| 1834 |
E. I. du Pont dies and leaves the property to his children. |
| 1837 |
Jacques Antoine Bidermann, an investor in E. I. du Pont's company, and his wife, Evelina, a daughter of E. I. du Pont, purchase the property from the other siblings and begin construction on a twelve-room mansion. They name it Winterthur after Bidermann's ancestral home in Switzerland. |
| 1839 |
Jacques Antoine and Evelina du Pont Bidermann move into the house at Winterthur. |
| 1863 |
Evelina du Pont Bidermann dies. |
| 1865 |
Jacques Antoine Bidermann dies. |
| 1867 |
Gen. Henry du Pont (brother of Evelina) purchases Winterthur from his nephew James Irénée Bidermann (son of Jacques and Evelina), for his own son Col. Henry Algernon du Pont. |
| 1876 |
Col. Henry Algernon and Pauline Foster du Pont, who married in 1874, settle at Winterthur. |
| 1880 |
Henry Francis du Pont is born to Col. Henry Algernon and Pauline Foster du Pont. |
| 1889 |
Gen. Henry du Pont dies; Col. Henry Algernon inherits Winterthur. |
| 1899 |
H. F. du Pont enters Harvard. |
| 1902 |
Col. Henry Algernon du Pont adds a new façade and library wing to the existing building at Winterthur. Pauline Foster du Pont dies. |
| 1903 |
H. F. du Pont graduates from Harvard and begins to manage the Winterthur household for his father. |
| 1909 |
H. F. du Pont takes over supervision of the gardens and grounds. |
| 1914 |
H. F. du Pont becomes manager of Winterthur Farms. |
| 1916 |
H. F. du Pont marries Ruth Wales. |
| 1927 |
H. F. du Pont inherits Winterthur after the death of his father, Henry Algernon, in late 1926. |
| 1928-32 |
A new wing is constructed, doubling the size of the existing building. |
| 1930 |
H. F. du Pont establishes the Winterthur Corporation, a nonprofit, educational foundation, with the intent of opening his home as a museum. |
| 1951 |
Winterthur opens to the public on October 30. |
| 1952 |
Winterthur Program in American Material Culture is established. First garden tour is given. |
| 1958 |
Winterthur fire department is established. |
| 1961 |
The Visitor Center opens as the visitor reception area. |
| 1966 |
Copeland Lecture Hall opens. |
| 1967 |
Ruth Wales du Pont dies. |
| 1969 |
H. F. du Pont dies. The Louise du Pont Crowninshield Research Building, named for his sister, opens. |
| 1974 |
Winterthur/University of Delaware Art Conservation program is established. |
| 1976 |
The Winterthur Guild is established. |
| 1978 |
First Point-to-Point; first Christmas tour (officially dubbed Yuletide at Winterthur in 1979). |
| 1992 |
The Galleries opens, including the Walter J. Laird Jr. Gallery. |
| 1993 |
The Henry S. McNeil Gallery opens. |
| 1994 |
The Thomas A. Graves Jr. Gallery for changing exhibitions opens. |
| 1997 |
The Campbell Collection of Soup Tureens at Winterthur opens in the new Dorrance Gallery. (The collection was donated to Winterthur in 1996.) |
| 2000 |
Director Leslie Greene Bowman introduces new vision for Winterthur as an American country estate. |
| 2001 |
Winterthur's 50th Anniversary; Enchanted WoodsTM, a new fairy-tale garden, opens. |